The association of 18F-FDG PET and glucose metabolism biomarkers GLUT1 and HK2 in p16 positive and negative head and neck squamous cell carcinomas

Autor: George S. Wilson, Andrew M. Baschnagel, Joshua T. Dilworth, Mohammad Eskandari, Lindsay Williams, Barbara L. Pruetz, Dafang Wu, Jessica Wobb
Rok vydání: 2015
Předmět:
Adult
Male
Oncology
endocrine system
medicine.medical_specialty
Cell
Kinesins
Standardized uptake value
Disease-Free Survival
Fluorodeoxyglucose F18
Internal medicine
Biomarkers
Tumor
medicine
Humans
Radiology
Nuclear Medicine and imaging
Aged
Aged
80 and over
Glucose Transporter Type 1
Human papillomavirus 16
Univariate analysis
biology
business.industry
Papillomavirus Infections
nutritional and metabolic diseases
Chemoradiotherapy
Hematology
Middle Aged
Prognosis
medicine.disease
Primary tumor
ErbB Receptors
carbohydrates (lipids)
Glucose
Treatment Outcome
medicine.anatomical_structure
Head and Neck Neoplasms
Positron-Emission Tomography
Carcinoma
Squamous Cell
Cancer research
biology.protein
Biomarker (medicine)
Immunohistochemistry
Female
GLUT1
business
hormones
hormone substitutes
and hormone antagonists
Zdroj: Radiotherapy and Oncology. 117:118-124
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2015.08.025
Popis: To investigate the relationship between FDG-PET maximum standard uptake value (SUVmax), p16, EGFR, GLUT1 and HK2 expression in head and neck squamous cell carcinomas (HNSCC).Immunohistochemical staining of p16, EGFR, GLUT1 and HK2 was performed on primary tumor tissue from 97 locally advanced HNSCC patients treated with definitive chemoradiation. SUVmax along with p16, EGFR, GLUT1 and HK2 expression were analyzed for associations including local control, locoregional control and disease free survival.Pretreatment SUVmax in primary tumors did not differ when stratified by p16, EGFR or GLUT1 expression but SUVmax was significantly higher in HK2 expressing tumors (p=0.021) and in tumors with higher T-stage (p=0.022). GLUT1 expression was significantly higher in p16 negative (p0.001) and EGFR positive tumors (p0.01). HK2 expressing tumors were associated with EGFR positive tumors (p=0.022) but not with p16 or GLUT1 expression. EGFR positive, p16 negative and high GLUT1 expressing tumors were associated with worse local control and disease free survival on univariate analyses. After adjusting for patient and treatment characteristics p16 status was the only factor that predicted for outcome on multivariate analysis.High GLUT1 expression was associated with EGFR positive and p16 negative HNSCC tumors. GLUT1 maybe an important biomarker in HNSCC but its expression appears dependent on p16 status.
Databáze: OpenAIRE
Externí odkaz: