Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
| Autor: | José Garcia, Christelle Serba, Nicolas Winssinger, Vincent Duplan, Sofia Barluenga, Gaëlle Valot |
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| Rok vydání: | 2012 |
| Předmět: |
Biological Products
cyclization Molecular Structure natural products Stereochemistry General Medicine General Chemistry Metathesis Sesquiterpene Combinatorial chemistry transition metals Catalysis Oxygen Lactones chemistry.chemical_compound Biosynthesis chemistry Cyclization Heterocyclic Compounds metathesis diversity-oriented synthesis Sesquiterpenes |
| Zdroj: | Angewandte Chemie: International Edition, Vol. 51, No 22 (2012) pp. 5391-5394 |
| ISSN: | 1433-7851 |
| Popis: | Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products. |
| Databáze: | OpenAIRE |
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