A STUDY OF CYTOTOXIC POTENTIAL AND ANTIOXIDANT ACTIVITY OF FRUIT OF ANNONA MURICATA

Autor: Oyinlade C. Ogundare
Rok vydání: 2020
Předmět:
DOI: 10.5281/zenodo.3864902
Popis: The use of various parts of Annona muricata (Sour Sop) in management of diseases cannot be over emphasized. This study considered the cytotoxic potential and antioxidant activity of A. muricata fruit. The crude aqueous extract of A. muricata fruit was screened for bioactive compounds and successively partitioned with n-hexane, ethyl acetate, acetone, acetic acid and methanol. The resulting fractions were evaluated for cytotoxicity using brine shrimp lethality assay (BSLA) and their antioxidant activity was determined using 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) scavenging ability. Alkaloids, glycosides, flavonoids, phenolics, saponins, steroids and carbohydrates were detected in the crude aqueous extract. Cytotoxicity of the ethyl acetate fraction was significantly (p0.05) lower than ascorbic acid. These results substantiated the presence of intermediate polar compound(s) with potential biological ability resulting from antiradical and consequential cytotoxic activity.
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