Repeated administration of subconvulsant doses of GABA antagonist drugs. II. Effect on monoamine-mediated behaviour
| Autor: | David J. Nutt, D.J. Heal, Angie Green, C C Batts, Philip J. Cowen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Agonist
Male Apomorphine medicine.drug_class Pharmacology Motor Activity Bicuculline Dopamine agonist Methamphetamine Receptors Dopamine GABA Antagonists chemistry.chemical_compound medicine Kindling Neurologic Animals Humans Picrotoxin Pentylenetetrazol Behavior Animal Quipazine Rats Inbred Strains GABA receptor antagonist Rats chemistry Receptors Serotonin Pentylenetetrazole Stereotyped Behavior medicine.drug |
| Popis: | The effect on monoamine-medical behaviour of repeated daily subconvulsive doses of the GABA antagonist drugs pentylenetetrazol (PTZ) (30 mg/kg for 8 days), picrotoxin (5 mg/kg for 4 days) and bicuculline (3.5 mg/kg for 16 days) was investigated. None of the drugs, administered chronically, increased behavioural responses to the 5-hydroxytryptamine agonist quipazine (25 mg/kg), and neither picrotoxin nor bicuculline altered the locomotor response to the dopamine agonist apomorphine (AP) (0.1 mg/kg). By contrast, repeated doses of PTZ increased the locomotor response to AP, and also increased circling responses to both AP (0.5 mg/kg) and methamphetamine (2.0 mg/kg) in unilateral nigrostriatal-lesioned rats. |
| Databáze: | OpenAIRE |
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