Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses
| Autor: | Kelsey A. Hart, Natalie Norton, Anne A. Wooldridge, D.M. Wochele, Dianne McFarlane, Nicholas Frank |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aging Hydrocortisone 040301 veterinary sciences Pituitary Diseases Standard Article 0403 veterinary science 03 medical and health sciences Insulin resistance Endocrinology Internal medicine medicine Pituitary pars intermedia dysfunction Hyperinsulinemia Animals Insulin Obesity Horses Steroid Metabolic Syndrome lcsh:Veterinary medicine Endocrine disease General Veterinary business.industry Equine 04 agricultural and veterinary sciences medicine.disease Standard Articles 030104 developmental biology Equine metabolic syndrome Case-Control Studies Body Composition lcsh:SF600-1100 Female Horse Diseases Seasons Metabolic syndrome EQUID Equine Metabolic Syndrome business Hormone medicine.drug |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of Veterinary Internal Medicine, Vol 30, Iss 2, Pp 653-663 (2016) |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | Background Increased free cortisol fraction is associated with insulin dysregulation (ID) in people with Metabolic Syndrome and Cushing's Disease. Free cortisol has not been investigated in equine endocrine disorders. Hypotheses (1) In healthy horses, sex, age, body condition score (BCS), and season impact free cortisol; (2) free cortisol is increased in horses with Pituitary Pars Intermedia Dysfunction (PPID) or Equine Metabolic Syndrome (EMS). Animals Fifty-seven healthy horses; 40 horses and ponies with PPID (n = 20) or EMS (n = 20). Methods Prospective study. Serum collected seasonally from healthy animals and archived serum from PPID and EMS animals was analyzed for insulin, total and free cortisol concentrations, and free cortisol fraction (FCF). Linear mixed models were used to determine effects of age, sex, season, and BCS on hormones in controls. Hormone measurements were compared between disease groups and age- and season-matched controls with t-tests. EMS and hyperinsulinemic PPID animals were combined in an ID (hyperinsulinemia) group. Results Free cortisol concentrations were increased in overweight/obese controls (0.3 ± 0.1 μg/dL) compared to lean controls (0.2 ± 0.1 μg/dL; P = .017). Mean FCF was significantly higher in animals with PPID (8.8 ± 5.8 μg/dL, P = .005) or ID (8.8 ± 10.2 μg/dL, P = .039) than controls (5.0 ± 0.9 μg/dL), but total cortisol concentrations were similar (P ≥ .350) (PPID: 4.2 ± 4.3 μg/dL; ID: 5.0 ± 4.5 μg/dL; controls: 4.6 ± 1.7 and 5.1 ± 2.1 μg/dL). Conclusions and clinical importance Increased FCF is associated with obesity in healthy horses and with ID (hyperinsulinemia) in horses and ponies with endocrine disease. Decreased plasma cortisol-binding capacity could be a component of these endocrine disorders in horses. |
| Databáze: | OpenAIRE |
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