Vasculogenic mimicry-potential target for glioblastoma therapy: an in vitro and in vivo study
| Autor: | Junzhe Xia, Minghua Zhuang, Cheng Luo, Yunjie Wang, Yinsheng Chen, Zhitao Jing, Zhongping Chen |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Angiogenesis Blotting Western Transplantation Heterologous CD34 Mice Nude Biology Neovascularization Mice Vasculogenesis In vivo medicine Animals Humans Vasculogenic mimicry neoplasms Neovascularization Pathologic Brain Neoplasms Hematology General Medicine Middle Aged Immunohistochemistry Transplantation Oncology Cancer research Neoplastic Stem Cells Female medicine.symptom Stem cell Glioblastoma |
| Zdroj: | Medical oncology (Northwood, London, England). 29(1) |
| ISSN: | 1559-131X |
| Popis: | Glioblastoma is one of the most angiogenic human tumors and characterized by microvascular proliferations. A better understanding of glioblastoma vasculature is needed to optimize anti-angiogenic therapy that has shown a promising but incomplete efficacy. The present study examined 48 glioblastomas by CD34 endothelial marker periodic acid-Schiff (PAS) dual staining and found non-endothelial cell-lined blood vessels that were formed by tumor cells (vasculogenic mimicry, VM) existing in a fraction of these tumors. We hypothesized that CD133-positive glioblastoma stem-like cells (GSCs) may play a pivotal role in glioblastoma VM formation and then demonstrated in vitro and in vivo that a subset of GSCs were capable of vasculogenesis. Moreover, we found that several growth factors involved in normal angiogenesis were expressed in GSCs. We describe here a new mechanism of alternative glioblastoma vascularization and open a new perspective for the anti-vascular treatment strategy. |
| Databáze: | OpenAIRE |
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