Leukocyte- and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy : a randomized clinical trial
| Autor: | Marcelo Marcucci, Leandro Chambrone, Luiz Felipe Palma, Cíntia Maria Remondes |
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| Přispěvatelé: | Chambrone, Leandro [0000-0002-2838-1015] |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Tooth extraction Osteoradionecrosis Visual analogue scale medicine.medical_treatment Dehiscence law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Platelet-Rich Fibrin Leukocytes medicine Humans Head and neck cancer General Dentistry Radiotherapy business.industry Research 030206 dentistry Perioperative medicine.disease CIENCIAS MÉDICAS [UNESCO] Platelet-rich fibrin Surgery Radiation therapy Otorhinolaryngology Head and Neck Neoplasms Tooth Extraction UNESCO::CIENCIAS MÉDICAS Oral Surgery business |
| Zdroj: | Palma, Luiz Felipe ; Marcucci, Marcelo ; Remondes, Cíntia Maria ; Chambrone, Leandro. Leukocyte-and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy : a randomized clinical trial. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 6 2020: 5 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Medicina Oral, Patología Oral y Cirugía Bucal Repositorio U. El Bosque Universidad El Bosque instacron:Universidad El Bosque RODERIC: Repositorio Institucional de la Universitat de Valéncia |
| Popis: | Background One of the most important complications of radiotherapy (RT) for head and neck cancer (HNC) is osteoradionecrosis (ORN) of the jaws, arising mainly from tooth extractions. Thus, the present study aimed to evaluate the efficacy of leukocyte- and platelet-rich fibrin (L-PRF) in preventing ORN following tooth extraction in post-irradiated HNC patients, as well as other postoperative complications. Material and Methods 23 patients previously submitted to conventionally fractionated 3D-conformational RT for HNC underwent atraumatic tooth extractions with perioperative antibiotic therapy. Besides, they were randomly assigned to receive L-PRF clots to fill and cover the extraction sockets (n=11, Test Group) or not (n=12, Control Group). A visual analog scale was used to quantify postoperative pain on the 3rd and 7th days. For ORN diagnosis, patients were clinically assessed for up to 180 days. Other postoperative complications (edema, alveolitis, suture dehiscence, continuous bleeding, and oroantral communication) were also evaluated within this period. Results No case of ORN or another surgical complication was observed and there were no differences in the postoperative pain scores between the groups on the 3rd and 7th days. Conclusions L-PRF did not seem to provide any additional benefits than those achieved by the combination of the surgical and drug protocols used for tooth extractions in the post-irradiated HNC patients. Key words:Radiotherapy, osteoradionecrosis, tooth extraction, head and neck cancer. |
| Databáze: | OpenAIRE |
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