Expression of MMIF, HIF-1α and VEGF in Serum and Endometrial Tissues of Patients with Endometriosis
| Autor: | Xiao-Ling Liu, Li-Ping Ruan, Hong-Ling Dong, Li-Ping Liu, Yu-Fang Xia, Wan Wang, Fan Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Vascular Endothelial Growth Factor A medicine.medical_specialty VEGF receptors Endometriosis Stage ii Biochemistry Gastroenterology Sensitivity and Specificity 03 medical and health sciences chemistry.chemical_compound Endometrium 0302 clinical medicine Internal medicine Genetics medicine Humans Clinical significance Stage (cooking) Macrophage Migration-Inhibitory Factors biology business.industry medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Vascular endothelial growth factor Blot Intramolecular Oxidoreductases 030104 developmental biology chemistry 030220 oncology & carcinogenesis Case-Control Studies biology.protein Macrophage migration inhibitory factor Female business |
| Zdroj: | Current medical science. 38(3) |
| ISSN: | 2523-899X |
| Popis: | The aim of this study was to investigate the expression of macrophage migration inhibitory factor (MMIF), hypoxia-inducible factor-1 a (HIF-1α) and vascular endothelial growth factor (VEGF) in the serum and endometrial tissues of patients with endometriosis (EM) and the clinical significance. Eighty EM patients [American Reproductive Association stage I (n=20), stage II (n=22), stage III (n=21) and stage IV (n=17)] were enrolled and divided into mild (10-14 points, n=28), moderate (16-24 points, n=27) and severe (26-30 points, n=25) dysmenorrhea groups. The control group included 40 healthy women of childbearing age who underwent routine healthcare examinations in the enrolment period. The expression of MMIF, HIF-1α and VEGF in the serum and endometrial tissues was measured by enzyme-linked immunosorbent assay and Western blotting, respectively. Meanwhile, the sensitivity and specificity of serum MMIF, HIF-1α, and VEGF when separately used as single indexes or jointly used as one index were examined as well. The results showed that serum concentrations of MMIF, HIF-1α, and VEGF were significantly higher in EM patients than in controls (P |
| Databáze: | OpenAIRE |
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