European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction
| Autor: | Giovanni Corona, Emmanuel Weyne, Carlo Bettocchi, Marcus M. Ilg, Maarten Albersen, Fabio Castiglione, Asif Muneer, Delphine Behr Roussel, Onur Omer Cakir, Javier Angulo, Yacov Reisman |
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| Přispěvatelé: | Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Funding: None. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Basic science Urology Endocrinology Diabetes and Metabolism medicine.medical_treatment [SDV]Life Sciences [q-bio] 030232 urology & nephrology MEDLINE lcsh:Medicine Review Dermatology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Endocrinology Erectile Dysfunction Sexual medicine medicine Intensive care medicine 030219 obstetrics & reproductive medicine Prostatectomy business.industry lcsh:R Guideline Evidence-based medicine lcsh:Other systems of medicine Nerve injury medicine.disease lcsh:RZ201-999 Radical Prostatectomy 3. Good health Psychiatry and Mental health Erectile dysfunction Reproductive Medicine Animal Model Cavernous Nerve medicine.symptom business |
| Zdroj: | Sexual Medicine, Vol 8, Iss 3, Pp 327-337 (2020) DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname Sexual Medicine Sexual Medicine, 2020, 8 (3), pp.327-337. ⟨10.1016/j.esxm.2020.06.007⟩ |
| ISSN: | 2050-1161 |
| DOI: | 10.1016/j.esxm.2020.06.007⟩ |
| Popis: | Introduction Rodent animal models are currently the most used in vivo model in translational studies looking into the pathophysiology of erectile dysfunction after nerve-sparing radical prostatectomy. Aim This European Society for Sexual Medicine (ESSM) statement aims to guide scientists toward utilization of the rodent model in an appropriate, timely, and proficient fashion. Methods MEDLINE and EMBASE databases were searched for basic science studies, using a rodent animal model, looking into the consequence of pelvic nerve injury on erectile function. Main outcome measures The authors present a consensus on how to best perform experiments with this rodent model, the details of the technique, and highlight possible pitfalls. Results Owing to the specific issue—basic science—Oxford 2011 Levels of Evidence criteria cannot be applied. However, ESSM statements on this topic will be provided in which we summarize the ESSM position on various aspects of the model such as the use of the Animal Research Reporting In Vivo Experiments guideline and the of common range parameter for nerve stimulation. We also highlighted the translational limits of the model. Conclusion The following statements were formulated as a suggestive guidance for scientists using the cavernous nerve injury model. With this, we hope to standardize and further improve the quality of research in this field. It must be noted that this model has its limitations. |
| Databáze: | OpenAIRE |
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