Inflammatory markers C-reactive protein and PLR in relation to HCC characteristics
| Autor: | Burcu Arslan, Halis Şimşek, Salih Tokmak, Ali Demir, Abdulalh Sonsuz, Hikmet Akkiz, Tuncer Temel, Gökhan Karakülah, Engin Altintaş, Ahmet Bektaş, Brian I. Carr, Figen Doran, Sezai Yilmaz, Tolga Akcam, Oğuz Üsküdar, Y. Tokat, Aslı Suner, Mehmet Demir, Tuğsan Ballı, Necati Örmeci, Mehmet Yücesoy, Ahmet Uygun, Sedef Kuran, Anıl Delik, Murat Kilic, Abdulalh Ülkü, Halil İbrahim Bahçeci, Nazım Ekinci, Ayşegül Özakyol, Kamil Yalçın Polat, Kendal Yalcin |
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| Přispěvatelé: | İç Hastalıkları |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Lymphocyte PLR Logistic regression Systemic inflammation Gastroenterology Article C-reactive protein NLR Internal medicine medicine HCC neoplasms Platelet lymphocyte ratio Receiver operating characteristic biology business.industry aggressiveness medicine.disease Portal vein thrombosis medicine.anatomical_structure Hepatocellular carcinoma biology.protein medicine.symptom business |
| Zdroj: | Journal of translational science |
| ISSN: | 2059-268X |
| Popis: | Introduction Several markers of systemic inflammation, including blood C-reactive protein, platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) have been identified as independent prognosticators for hepatocellular carcinoma (HCC). Methods To attempt to understand the significance of these markers, they were examined in relation to 4 tumour parameters, namely maximum tumour diameter (MTD), tumour multifocality, portal vein thrombosis (PVT) and blood alpha-fetoprotein (AFP) levels. Results Using linear and logistic regression models, we found that C-reactive protein and PLR on single variables, were statistically significantly related to the tumour parameters. In a logistic regression final model, CRP was significantly related to MTD, AFP and PVT, and the Glasgow Index significantly related to MTD and AFP. Results of the area under the receiver operating characteristic curves (ROC), showed that the areas for PLR and CRP were statistically significant for high versus low MTD and for presence versus absence of PVT. CRP alone was significant for high versus low AFP. Conclusions These analyses suggest that the prognostic usefulness of the inflammatory markers PLR and CRP (but not NLR) may be due to their reflection of parameter values for tumour growth and invasiveness. |
| Databáze: | OpenAIRE |
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