Standardisation and application of the single-breath determination of nitric oxide uptake in the lung
| Autor: | Ivo van der Lee, Gerald S. Zavorsky, Connie C. W. Hsia, Jiguo Cao, Robert Naeije, Colin Borland, Hervé Guénard, Anh Tuan Dinh-Xuan, J. Michael B. Hughes, Irene Steenbruggen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Adolescent Analytical chemistry chemistry.chemical_element Blood volume 030204 cardiovascular system & hematology Nitric Oxide Oxygen law.invention Nitric oxide Pulmonary function testing Capillary Permeability Hemoglobins Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Alveolar gas equation law Diffusing capacity Humans Medicine Aged Chemiluminescence Aged 80 and over Carbon Monoxide Blood Volume business.industry Middle Aged Pulmonary Alveoli 030228 respiratory system chemistry Linear Models Pulmonary Diffusing Capacity Female business Carbon monoxide |
| Zdroj: | European Respiratory Journal. 49:1600962 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/13993003.00962-2016 |
| Popis: | Diffusing capacity of the lung for nitric oxide (DLNO), otherwise known as the transfer factor, was first measured in 1983. This document standardises the technique and application of single-breathDLNO. This panel agrees that 1) pulmonary function systems should allow for mixing and measurement of both nitric oxide (NO) and carbon monoxide (CO) gases directly from an inspiratory reservoir just before use, with expired concentrations measured from an alveolar “collection” or continuously sampledviarapid gas analysers; 2) breath-hold time should be 10 s with chemiluminescence NO analysers, or 4–6 s to accommodate the smaller detection range of the NO electrochemical cell; 3) inspired NO and oxygen concentrations should be 40–60 ppm and close to 21%, respectively; 4) the alveolar oxygen tension (PAO2) should be measured by sampling the expired gas; 5) a finite specific conductance in the blood for NO (θNO) should be assumed as 4.5 mL·min-1·mmHg-1·mL-1of blood; 6) the equation for 1/θCO should be (0.0062·PAO2+1.16)·(ideal haemoglobin/measured haemoglobin) based on breath-holdingPAO2and adjusted to an average haemoglobin concentration (male 14.6 g·dL−1, female 13.4 g·dL−1); 7) a membrane diffusing capacity ratio (DMNO/DMCO) should be 1.97, based on tissue diffusivity. |
| Databáze: | OpenAIRE |
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