Azathioprine versus D-penicillamine in rheumatoid arthritis patients who have been treated unsuccessfully with gold
| Autor: | H. James Williams, Arthur Weinstein, Marilyn A. Solsky, James C. Reading, Ronald L. Wilder, Graciela S. Alarcón, Marlene J. Egger, Maria Guttadauria, Robert F. Willkens, Edmund J. Maclaughlin, Robert F. Meenan, Harold E. Paulus, Stanley B. Kaplan, Miki L. Coleman, John R. Ward, Cecil O. Samuelson |
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| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Nausea Immunology Azathioprine Gastroenterology Arthritis Rheumatoid Random Allocation Rheumatology Double-Blind Method Internal medicine Multicenter trial medicine Immunology and Allergy Humans Pharmacology (medical) Clinical Trials as Topic Leukopenia medicine.diagnostic_test business.industry Penicillamine Middle Aged medicine.disease Rash Dysgeusia Surgery Rheumatoid arthritis Erythrocyte sedimentation rate Female Gold medicine.symptom business medicine.drug |
| Zdroj: | Arthritis and rheumatism. 27(7) |
| ISSN: | 0004-3591 |
| Popis: | Two hundred six patients were entered into a prospective controlled, double-blind, multicenter trial comparing azathioprine (AZA) 1.25–1.5 mg/kg/day with D-penicillamine (DP) 10–12 mg/kg/day. One hundred thirty-four patients completed 24 weeks of therapy. Improvement in nearly all efficacy variables was seen in both groups. Patients taking DP demonstrated a greater rise in hemoglobin concentration and greater fall in erythrocyte sedimentation rate than patients receiving AZA; these were the only efficacy variables with a significant difference between the treatment groups. Fewer withdrawals for adverse reactions occurred among the patients receiving AZA, but the difference was not significant. Patients receiving AZA were withdrawn from the drug mainly for abnormal liver function test results, nausea and gastrointestinal upset, and leukopenia. The main reasons for withdrawal of patients receiving DP were nausea, rash and pruritis, thrombo-cytopenia, dysgeusia, and proteinuria. |
| Databáze: | OpenAIRE |
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