Tolerance of organ transplant recipients to physical activity during a high-altitude expedition
| Autor: | Greetje Kuiken, Cees P. van der Schans, Edwin J. van Adrichem, Janneke M. Dilling, Erik A M Verschuuren, Bart L. Rottier, Marion J. Siebelink |
|---|---|
| Přispěvatelé: | Healthy Ageing, Allied Health Care and Nursing, Extremities Pain and Disability (EXPAND), Health Psychology Research (HPR), Groningen Institute for Organ Transplantation (GIOT), Groningen Research Institute for Asthma and COPD (GRIAC) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
mountaineering
medicine.medical_treatment lcsh:Medicine spierkracht vrouwelijk Liver transplantation hartslag Organ transplantation middle aged adults heart rate Medicine lcsh:Science Prospective cohort study humans Altitude sickness Multidisciplinary transplant recipients VALUES organ transplantation SUCCESS blood pressure acclimatisatie acclimatization surgical procedures operative transplantatiepatiënten toekomstige studies medicine.symptom Research Article altitude medicine.medical_specialty non-U.S. Gov't hoogte exercise test tanzania oefeningstest middelbaar hoogteziekte esearch support non-U.S. Gov't esearch support Internal medicine mensen Heart rate Hyperventilation tijdschriftartikel orgaantransplantatie expedities volwassene business.industry HAND-HELD DYNAMOMETRY alpinisme lcsh:R altitude sickness case control study medicine.disease prospective studies Surgery Transplantation Blood pressure muscle strength lcsh:Q business expeditions bloeddruk |
| Zdroj: | PLoS ONE, 10(11). Public Library of Science PLoS ONE, 10(11):e0142641. PUBLIC LIBRARY SCIENCE PLoS ONE, Vol 10, Iss 11, p e0142641 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0142641 |
| Popis: | BackgroundIt is generally unknown to what extent organ transplant recipients can be physically challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous physical activity and high-altitude of organ transplant recipients after various types of transplantation was compared to non-transplanted controls.MethodsTwelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-, 4 liver-, 1 allogeneic stem cell-and 1 small bowel-transplantation). Controls comprised the members of the medical team and accompanying family members (n = 14). During the climb, cardiopulmonary parameters and symptoms of acute mountain sickness were recorded twice daily. Capillary blood analyses were performed three times during the climb and once following return.ResultsEleven of the transplant participants and all controls began the final ascent from 4700 meters and reached over 5000 meters. Eight transplant participants (73%) and thirteen controls (93%) reached the summit (5895m). Cardiopulmonary parameters and altitude sickness scores demonstrated no differences between transplant participants and controls. Signs of hyperventilation were more pronounced in transplant participants and adaptation to high-altitude was less effective, which was related to a decreased renal function. This resulted in reduced metabolic compensation.ConclusionOverall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition in carefully selected organ transplant recipients is comparable to non-transplanted controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|