Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
| Autor: | Siegfried Hoyer, Heinrich Lannert |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Glucose
Male medicine.medical_treatment Carbohydrate metabolism Statistics Nonparametric Streptozocin Behavioral Neuroscience Adenosine Triphosphate Alzheimer Disease Memory Avoidance Learning medicine Animals Dementia Rats Wistar Habituation Habituation Psychophysiologic Behavior Animal biology Working memory Insulin Brain Streptozotocin medicine.disease Receptor Insulin Rats Adenosine Diphosphate Disease Models Animal Insulin receptor Practice Psychological biology.protein Alzheimer's disease Energy Metabolism Psychology Neuroscience medicine.drug |
| Zdroj: | Behavioral Neuroscience. 112:1199-1208 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/0735-7044.112.5.1199 |
| Popis: | Drastic abnormalities have been demonstrated to occur in cerebral glucose and energy metabolism in sporadic Alzheimer's disease, pointing to a primary disturbance in neuronal insulin and insulin receptor signal transduction and contributing to the causation of dementia. The compound streptozotocin (STZ) is known to inhibit insulin receptor function. The study was designed to investigate whether intracerebroventricularly (icv) applied STZ would inhibit neuronal insulin receptor function and would induce changes in both behavior and neuronal energy metabolism. Adult rats with icv-injected STZ developed long-term and progressive deficits in learning, memory, and cognitive behavior, indicated by decreases in working and reference memory in the holeboard task and the passive avoidance paradigm, along with a permanent and ongoing cerebral energy deficit. This animal model may be appropriate for investigations related to sporadic Alzheimer's dementia. |
| Databáze: | OpenAIRE |
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