Corneal Nerve and Brain Imaging in Mild Cognitive Impairment and Dementia
| Autor: | Essa Al-Sulaiti, Ioannis N. Petropoulos, Shafi Khan, Pravija Manikoth, Ahmed Own, Marwan Ramadan, Surjith Vattoth, Maryam Alobaidi, Ahmed Elsotouhy, Adnan Khan, Anoop Sankaranarayanan, Yasmin Hamdi, Masharig Gadelseed, Georgios Ponirakis, Navas Nadukkandiyil, Anjum Arasn, Mani Chandran, Marwa Elorrabi, Ziyad Mahfoud, Ashfaq Shuaib, Susan Osman, Hamad Almuhannadi, Hoda Gad, Hanadi Al Hamad, Noushad Thodi, Rayaz A. Malik, Priya V Gawhale, Eiman Al-Janahi, Rhia Tosino |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Corneal nerve corneal nerve fibers Medial temporal atrophy Ophthalmic Nerve Neuropathology Cornea 03 medical and health sciences mild cognitive impairment 0302 clinical medicine Neuroimaging Ophthalmology medicine Humans Dementia Cognitive Dysfunction Cognitive impairment Aged Aged 80 and over neuropathology Microscopy Confocal business.industry General Neuroscience Brain General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Corneal confocal microscopy 030221 ophthalmology & optometry Biomarker (medicine) Female Geriatrics and Gerontology Fiber density business 030217 neurology & neurosurgery Research Article medial temporal lobe atrophy |
| Zdroj: | Journal of Alzheimer's Disease |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-200678 |
| Popis: | Background: Visual rating of medial temporal lobe atrophy (MTA) is an accepted structural neuroimaging marker of Alzheimer’s disease. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic technique that detects neuronal loss in peripheral and central neurodegenerative disorders. Objective: To determine the diagnostic accuracy of CCM for mild cognitive impairment (MCI) and dementia compared to medial temporal lobe atrophy (MTA) rating on MRI. Methods: Subjects aged 60–85 with no cognitive impairment (NCI), MCI, and dementia based on the ICD-10 criteria were recruited. Subjects underwent cognitive screening, CCM, and MTA rating on MRI. Results: 182 subjects with NCI (n = 36), MCI (n = 80), and dementia (n = 66), including AD (n = 19, 28.8%), VaD (n = 13, 19.7%), and mixed AD (n = 34, 51.5%) were studied. CCM showed a progressive reduction in corneal nerve fiber density (CNFD, fibers/mm2) (32.0±7.5 versus 24.5±9.6 and 20.8±9.3, p |
| Databáze: | OpenAIRE |
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