Correlation of fundus fluorescein angiography and spectral-domain optical coherence tomography in identification of membrane subtypes in neovascular age-related macular degeneration
| Autor: | Raeba Mathew, Manpreet Brar, Maria Pefkianaki, Matthew Richardson, Sobha Sivaprasad, Nickolaos Kopsachilis |
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| Rok vydání: | 2013 |
| Předmět: |
Indocyanine Green
Male Vascular Endothelial Growth Factor A medicine.medical_specialty genetic structures Angiogenesis Inhibitors Antibodies Monoclonal Humanized Sensitivity and Specificity Correlation chemistry.chemical_compound Optics Optical coherence tomography Ophthalmology Ranibizumab medicine Humans Fluorescein Angiography Fundus fluorescein angiography Aged Fluorescent Dyes Retrospective Studies medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Macular degeneration Fluorescein angiography medicine.disease eye diseases Sensory Systems Choroidal Neovascularization Choroidal neovascularization chemistry Wet Macular Degeneration Female sense organs medicine.symptom business Indocyanine green Tomography Optical Coherence medicine.drug |
| Zdroj: | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 231(3) |
| ISSN: | 1423-0267 |
| Popis: | Aims: To assess the sensitivity and specificity of spectral-domain optical coherence tomography (SDOCT) for the determination of choroidal neovascularization (CNV) subtypes in neovascular age-related macular degeneration (AMD) compared to fundus fluorescein angiography (FFA) and also the agreement between the two procedures. Design: This was a retrospective, observational study. Methods: We evaluated and compared the CNV subtypes on FFA and OCT in 100 eyes initiated on ranibizumab for neovascular AMD. Results: SDOCT showed high sensitivity (85.7-98.3%) and specificity (84.2-100%) compared to FFA in the diagnosis of the CNV subtype. The area under the receiver-operating characteristic curve ranged from 0.9 to 0.93 (p value Conclusion: SDOCT is a reliable tool for the diagnosis of CNV subtypes in neovascular AMD obviating the need for an invasive procedure such as FFA. |
| Databáze: | OpenAIRE |
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