HLA-DMB gene and HLA-DRA promoter region polymorphisms in Australian multiple sclerosis patients
| Autor: | Marc McW Buhler, Suzy Teutsch, Robert Heard, Bruce Bennetts, Graeme J. Stewart |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
musculoskeletal diseases
Linkage disequilibrium Multiple Sclerosis Immunology Population HLA-DR alpha-Chains Locus (genetics) Biology HLA-DRA Humans Immunology and Allergy Allele Promoter Regions Genetic skin and connective tissue diseases education Genetics HLA-D Antigens education.field_of_study Polymorphism Genetic Haplotype Australia Histocompatibility Antigens Class II Epistasis Genetic Promoter HLA-DR Antigens General Medicine Molecular biology HLA-DMB |
| Zdroj: | Human Immunology. 60:886-893 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/s0198-8859(99)00054-3 |
| Popis: | The MHC region has been shown to contain a susceptibility locus for multiple sclerosis (MS). While the strongest association to date has been between HLA-DRB1∗1501 and MS, the exact nature of the MHC association in MS remains unclear. Two candidate polymorphic loci within the MHC class II region, the HLA-DMB gene and the HLA-DRA promoter, which lie close to HLA-DRB1, were therefore examined in an Australian MS population. The HLA-DMB∗0103 phenotype was increased in the MS patients (46% vs. 30%) and the frequency of the HLA-DRA promoter A allele was also increased (81% vs. 68%). When the subjects were stratified into HLA-DRB1∗1501 positive and negative individuals these associations were not significantly different. This is a result of the strong linkage disequilibrium between HLA-DRB1∗1501 and both HLA-DMB∗0103 and the HLA-DRA promoter A allele. The complete linkage between DRB1∗1501 and the HLA-DRA promoter A allele indicates that the MS susceptibility haplotype (DRB1∗1501-HLA-DQB1∗0602-HLA-DQA1∗0102) can be extended out to promoter of the HLA-DRA locus. Interactions between both HLA-DMB and the HLA-DRA promoter and other reported MS susceptibility loci were examined (TCRBV polymorphisms, HLA-DQA1 and HLA-DQB1). Some interactions between specific TCRBV polymorphisms and the HLA-DRA promoter were observed, which is consistent with other published reports suggesting an epistatic interaction between TCRBV and HLA-DRB1. |
| Databáze: | OpenAIRE |
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