| Popis: |
Telmisartan is used in the treatment of Hypertension (high blood pressure), prevention of heart attacks, strokes and heart failure. It is an angiotensin II type -1 receptor antagonist. Telmisartan belongs to class II under biopharmaceutical classification system. Hence, the solubility is the main issue. To increase the oral absorption, telmisartan requires enhancement in solubility and dissolution. The present study was aimed to increase the solubility of telmisartan by various techniques such as complexation and Solid dispersion. The tablet formulation was prepared to enhance the solubility and dissolution and compared with the drug release profile of the marketed preparation. |
