Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor
| Autor: | Yu Li, Danilo Correddu, Tobias Gruber, Richard J. Hopkinson, Akane Kawamura, Kamal Patel, Ivanhoe K. H. Leung, Thomas Hanauer, Vijayalekshmi Sarojini |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry F160 Organic Chemistry 0104 chemical sciences Histone biology.protein C720 Biological Chemistry Molecule F100 Chemistry Epigenetics Physical and Theoretical Chemistry Receptor |
| Popis: | Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation. |
| Databáze: | OpenAIRE |
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