A Ligand-Modulated Padlock Oligonucleotide for Supercoiled Plasmids

Autor:	Thibaut Roulon, Claude Hélène, Christophe Escudé
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Stereochemistry Oligonucleotide fungi Catenane Supramolecular chemistry food and beverages General Chemistry General Medicine Ligand (biochemistry) Catalysis Catenation Plasmid chemistry Supercoiled plasmid Non-covalent interactions
Zdroj:	Angewandte Chemie. 113:1571-1574
ISSN:	1521-3757 0044-8249
DOI:	10.1002/1521-3757(20010417)113:8<1571::aid-ange1571>3.0.co;2-z
Popis:	Catenation of a circular oligonucleotide to a supercoiled plasmid can be achieved in high yields by means of ligand-induced triple-helix formation. The noncovalent interactions in this supramolecular structure can be modulated by a triplex-stabilizing agent (TSA; see picture). The circular oligonucleotide represents a noncovalent anchor for plasmid functionalization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc43b29e25394810b1e053166088c20 https://doi.org/10.1002/1521-3757(20010417)113:8<1571::aid-ange1571>3.0.co Zobrazit plný text záznamu Plný text