Motor behavior correlates with striatal [(1)(8)F]-DOPA uptake in MPTP-lesioned primates
| Autor: | S.A. Eshuis, Klaus L. Leenders, G. Andringa, Rudie Kortekaas, A.R. Cools |
|---|---|
| Přispěvatelé: | Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE) |
| Rok vydání: | 2013 |
| Předmět: |
Primates
medicine.medical_specialty Movement disorders Parkinson's disease DCN MP - Plasticity and memory FDOPA UPTAKE Striatum Cellular and Molecular Neuroscience chemistry.chemical_compound PARKINSONS-DISEASE Dopaminergic cell groups Dopamine Internal medicine medicine CLINICAL CHANGES DRUG MPTP [F-18]-F-DOPA TCH346 Dopaminergic Cell Biology medicine.disease nervous system diseases PET Endocrinology chemistry nervous system MPTP Poisoning TRIAL medicine.symptom Psychology Neuroscience MONKEY MODEL medicine.drug |
| Zdroj: | Neurochemistry International, 62, 4, pp. 349-53 Neurochemistry International, 62, 349-53 Neurochemistry International, 62(4), 349-353. PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0197-0186 |
| DOI: | 10.1016/j.neuint.2013.01.021 |
| Popis: | The MPTP-lesioned monkey is considered as the best animal model for Parkinson's disease (PD). It has damage to dopaminergic cell groups and motor dysfunction similar to that seen in PD. Correlations between these two parameters have been described but there is a lack of formal statistical analyses on dopaminergic function as assessed by [F-18]-F-DOPA PET and objectively rated motor behavior in longitudinal experiments.Eight rhesus monkeys received two MPTP infusions: first in one carotid artery, and after eight weeks in the other. Motor behavior and [F-18]-F-DOPA uptake were measured at three stages: baseline, unilateral and bilateral. We correlated movement with radiotracer uptake across these three stages. MPTP caused the expected parkinsonian motor signs which were accompanied by lower radioactivity concentrations in the striatum. There were significant correlations between dopaminergic function and behavior.In conclusion, striatal [F-18]-F-DOPA uptake correlates inversely with the severity of motor impairment in MPTP-lesioned non-human primates. Both behavioral scoring and [F-18]-F-DOPA PET scans are useful and sensitive methods to monitor dopaminergic degeneration within subjects. (C) 2013 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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