Advances in leprosy immunology and the field application: A gap to bridge

Autor: Ben Naafs, Pranab Kumar Das, David A. Lammas, Vania Nieto Brito de Souza, Anand Iyer
Přispěvatelé: Amsterdam institute for Infection and Immunity, Pathology, Human Genetics, Amsterdam Neuroscience - Neuroinfection & -inflammation
Rok vydání: 2016
Předmět:
Zdroj: Clinics in dermatology, 34(1), 82-95. Elsevier Inc.
ISSN: 1879-1131
0738-081X
Popis: Advances concerning the hosts' immune response to Mycobacterium leprae infection have focused on elucidating the immune pathomechanisms involved, with the hope that predictive diagnostic and prognostic parameters (biomarkers) for field use would emerge; however, improvements in our understanding of the immunologic responses to this complex disease have, to date, somewhat failed to provide the effective and robust methods for improving its predictive diagnosis in the field situation, particularly in those patients suffering from paucibacillary disease. In this contribution we have attempted to review some of the advances both in the immunology and immunopathology of leprosy, and also highlight the limited clusters of immune parameters that are now available. Most importantly, we point out the limitations that still prevail in the provision of effective biomarkers in the field situation for either: (1) the diagnosis of indeterminate disease, (2) predictive diagnosis of individuals developing reactional states, (3) monitoring efficacy of treatment, or (4) monitoring treatment of reactional states.
Databáze: OpenAIRE
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