The effect of the management with fresh frozen plasma on the outcome of patients with acute organophosphate poisoning
| Autor: | Sameh Saad, Monira Taha Ismail, Rania K.H. Hashish, Mohamed Abdel Aal, Gouda M Ellabban, Rehab I. Abdel-Karim |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
fresh frozen plasma lcsh:Medicine 010501 environmental sciences 01 natural sciences Organophosphate poisoning law.invention 03 medical and health sciences Randomized controlled trial law Intensive care Suez canal Medicine 0105 earth and related environmental sciences business.industry lcsh:R Cholinesterase level Emergency department medicine.disease Atropine 030104 developmental biology Anesthesia Forensic sciences Fresh frozen plasma business toxicology medicine.drug |
| Zdroj: | International Journal of Surgery and Medicine, Vol 3, Iss 2 (2017) |
| ISSN: | 2367-7414 |
| DOI: | 10.5455/ijsm.fresh-frozen-plasma-organophosphate-poisoning |
| Popis: | Background: Organophosphate (OP) poisoning is an important reason for hospitals and intensive care units admission in the developing countries. OP poisoning patients are classically treated with atropine and oximes, these methods are sometimes shown to be of limited benefit. Objective: Assessment of the effectiveness of the management with fresh frozen plasma (FFP) in improving the outcome of patients with acute OP poisoning. Patient and Methods: A randomized clinical trial study was conducted upon 70 acute OP poisoning patients that were referred to the Emergency Department, Suez Canal University Hospital, Ismailia, Egypt. These patients were randomly divided into two groups (35 each); Control group: Treated with the traditional management protocol of OP (atropine and oximes). FFP group: Treated with the traditional management protocol of OP plus FFP. Results: No significant difference was found in cholinesterase level on admission between both groups, Serum cholinesterase level in the FFP group significantly increased after an hour of FFP infusion (2.48 iu/ml vs. 10.36 iu/ml p |
| Databáze: | OpenAIRE |
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