POSSIBLE CARDIOPROTECTIVE ACTION OF POMEGRANATE JUICE PUNICA GRANATUM AND PROPOLIS AGAINST MYOCARDIAL INFARCTION INDUCED IN RATS
| Autor: | Ghadeer Turki Aloutaibi, Abdulrahman L. Al Malki, Hanaa Gashlan, Said S Moselhy, Jehan A. Khan |
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| Rok vydání: | 2017 |
| Předmět: |
Cardiac marker
Negative control Pharmacology 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology 0302 clinical medicine Lactate dehydrogenase Drug Discovery Medicine Myocardial infarction biology Traditional medicine business.industry 04 agricultural and veterinary sciences Propolis medicine.disease biology.organism_classification 040401 food science Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Punica biology.protein Standard diet Creatine kinase Pomegranate juice Propolis Myocardial infarction Rats business |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines; Vol 14, No 5 (2017); 138-146 |
| ISSN: | 2505-0044 0189-6016 |
| DOI: | 10.21010/ajtcam.v14i5.17 |
| Popis: | Background: The present study was conducted to evaluate the protective role of pomegranate juice alone or in combination with propolis extract against isoproterenol (ISO) induced myocardial infarction in rats.Material and Methods: Male Wister albino rats (n=60) weighing 220-280g were divided into six groups each group contain ten rats; group I: negative control fed standard diet. Group (II-VI): Rats were injected subcutaneously with isoproterenol (150 mg/kg) for 3 days. Group III: Rats were given pomegranate juice 1ml /rat / day. Group IV: Rats were given propolis extract (50 mg/kg BW). Group V: Rats were given pomegranate juice + propolis extract. Group VI: Rats were given glyceronitrate (2.6mg/kg.bw/day).Results: The ISO-induced myocardial infarction in untreated rats has indicated by significant (p < 0.001) elevation of cardiac marker enzymes such as aspartate aminotransferase (AST), Lactate dehydrogenase (LDH), creatine kinase (CK), and cardiac troponin I (CnI ) when compared with control group. Rats treated with pomegranate juice and propolis extracts showed highly significant (p |
| Databáze: | OpenAIRE |
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