Author Correction: Airway response to respiratory syncytial virus has incidental antibacterial effects
| Autor: | Joyce M. Ngoi, Timothy Chege, Simon B. Drysdale, James A. Berkley, Charles J. Sande, Martin Mutunga, David James Nokes, E M Gardiner, Christopher A Green, Andrew J. Pollard, James M. Njunge, Elijah Gicheru, Agnes Gwela |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Proteomics
Neutrophils Science General Physics and Astronomy 02 engineering and technology Respiratory Mucosa Respiratory Syncytial Virus Infections General Biochemistry Genetics and Molecular Biology Virus Cell Degranulation 03 medical and health sciences Medicine Humans Respiratory system lcsh:Science Author Correction 030304 developmental biology 0303 health sciences Multidisciplinary business.industry Microbiota Infant Newborn Infant Streptococcus General Chemistry Bacterial Infections 021001 nanoscience & nanotechnology Kenya 3. Good health Child Preschool Respiratory Syncytial Virus Human Immunology Infectious diseases Mucosal immunology lcsh:Q Metagenomics 0210 nano-technology Airway business Infection |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019) |
| ISSN: | 2041-1723 |
| Popis: | RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time of RSV infection compared with samples collected one month later. RSV infection is associated with neutrophil influx into the airway and degranulation and is marked by overexpression of proteins with known antibacterial activity including BPI, EPX, MPO and AZU1. Airway secretions of children infected with RSV, have significantly greater antibacterial activity compared to RSV-negative controls. This RSV-associated, neutrophil-mediated antibacterial response in the airway appears to act as a regulatory mechanism that modulates bacterial growth in the airways of RSV-infected children. |
| Databáze: | OpenAIRE |
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