Learning from history: Lord Brain and Hashimoto’s encephalopathy
| Autor: | James D. Berry, Grace F. Crotty, Martin A. Samuels, Isaac H. Solomon, Colin P. Doherty |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Encephalopathy Hashimoto's encephalopathy Hashimoto Disease Disease 030230 surgery Methylprednisolone Creutzfeldt-Jakob Syndrome Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Autoimmune encephalopathy mental disorders medicine Humans Clinical care Autoantibodies Brain Diseases business.industry Thyroid disease Not Otherwise Specified General Medicine Middle Aged medicine.disease nervous system diseases Encephalitis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Practical Neurology. 19:316-320 |
| ISSN: | 1474-7766 1474-7758 |
| Popis: | We present two historic cases of severe encephalopathy associated with antithyroid antibodies. The first was published by Lord Brain of Eynsham, and the second was from our department’s archives. Although both cases are from archival sources, they continue to inform current clinical care. We briefly review the poorly defined entity, Hashimoto’s encephalopathy, and discuss diagnostic advances for autoimmune encephalopathy and for Creutzfeldt-Jakob disease. We advocate for giving a trial of corticosteroids to patients with ‘encephalopathy, not otherwise specified’ while awaiting antibody results or more definitive testing. Our case, initially diagnosed as having Creutzfeldt-Jakob disease, responded remarkably (with video evidence) to a trial of corticosteroids. |
| Databáze: | OpenAIRE |
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