Oncological benefit of re‐resection for T1 bladder cancer: a comparative effectiveness study
| Autor: | Rinku Sutradhar, Syed R. Qadri, Thomas Hermanns, Ning Liu, Nancy N. Baxter, Kathy Li, Marian S. Wettstein, Muhammad Mamdani, Pham Song, Theodorus H. van der Kwast, Girish S. Kulkarni |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Urology Hazard ratio Confounding Cystectomy Prognosis Confidence interval Urinary Bladder Neoplasms Interquartile range Internal medicine Statistical significance Cohort medicine Humans Urologic Surgical Procedures business Survival analysis Neoplasm Staging Retrospective Studies Cohort study |
| Zdroj: | BJU International. 129:258-268 |
| ISSN: | 1464-410X 1464-4096 |
| Popis: | OBJECTIVES: To quantify the real-world survival benefit of re-resection vs no re-resection in patients diagnosed with T1 bladder cancer (BC) at the population level. PATIENTS AND METHODS: Retrospective population-wide observational cohort study based on pathology reports linked to health administrative data. We identified patients who were diagnosed with T1 BC in the province of Ontario (01/2001-12/2015) and used billing claims to ascertain whether they received re-resection within 2-10 weeks. The time-dependent effect of re-resection on survival outcomes was modelled by Cox proportional hazards regression (unadjusted and adjusted for numerous assumed patient- and surgeon-level confounding variables). Effect measures were presented as hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: We identified 7666 patients of which 2162 (28.7%) underwent re-resection after a median (interquartile range) time of 45 (35-56) days. Patients who received re-resection were less likely to die from any causes (HR 0.68, 95% CI 0.63-0.74, P |
| Databáze: | OpenAIRE |
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