Encapsulation of monoamine neurotransmitters and trace amines by amphiphilic anionic calix[5]arene micelles
| Autor: | Giuseppe Gattuso, Ilenia Pisagatti, Melchiorre F. Parisi, Salvatore Patanè, Sebastiano Pappalardo, Anna Notti |
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| Rok vydání: | 2014 |
| Předmět: |
Phenethylamine
calixarenes micelles DOSY AFM neurotransmitters Hydrochloride Cationic polymerization macromolecular substances General Chemistry Tyramine Micelle Catalysis chemistry.chemical_compound Monoamine neurotransmitter chemistry Amphiphile Polymer chemistry Materials Chemistry Organic chemistry Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | New J. Chem.. 38:5983-5990 |
| ISSN: | 1369-9261 1144-0546 |
| Popis: | The interactions between hydrochloride salts of biologically relevant amines and micelles formed by a water-soluble p-tert-butylcalix[5]arene were investigated by means of 1H NMR spectroscopy, using a combination of NOESY and DOSY techniques. DOSY measurements were conveniently employed to assess the micelle affinity towards the target guests (phenylethylamine ≈ histamine ≈ serotonin > tyramine > dopamine > norepinephrine), whereas NOESY studies revealed the approximate position of these cationic guests within the different micellar regions. In general, all the guests were located in the palisade region of the micelle, with the exception of phenethylamine and histamine, the former being bound to the micellar core as well as the palisade, the latter preferring the outer shell of the micelle. |
| Databáze: | OpenAIRE |
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