The D allele of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with worse functional outcome of ischaemic stroke
| Autor: | Sri Sutarni, Rusdy Ghazali Malueka, Abdul Gofir, Ery Kus Dwianingsih, Ismail Setyopranoto, Halwan Fuad Bayuangga, Rheza Gandi Bawono |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Genotype Ace gene Peptidyl-Dipeptidase A Brain Ischemia Pathogenesis 03 medical and health sciences I d polymorphism 0302 clinical medicine Gene Frequency INDEL Mutation Risk Factors Internal medicine Ischaemic stroke Activities of Daily Living Medicine Insertion deletion Humans Genetic Predisposition to Disease 030212 general & internal medicine Allele Aged biology business.industry General Neuroscience Angiotensin-converting enzyme General Medicine Middle Aged Ace polymorphism Stroke Endocrinology Cross-Sectional Studies biology.protein Female business 030217 neurology & neurosurgery |
| Zdroj: | The International journal of neuroscience. 128(8) |
| ISSN: | 1563-5279 |
| Popis: | Insertion/deletion polymorphism in ACE gene (ACE I/D) is known to be associated with the occurrence of ischaemic stroke through its effect on pathogenesis of atherosclerosis and hypertension. This study was aimed to examine the association between this polymorphism with functional outcome of ischaemic stroke.This was a cross-sectional study. The subjects were patients with ischaemic stroke in a reference hospital in Yogyakarta, Indonesia. Data on demographic characteristics, stroke risk factors, comorbidities and stroke severity were assessed on admission. The functional outcome, Barthel index (BI), was assessed when the patients were discharged from the hospital. ACE I/D genotypes of the patients were identified by polymerase chain reaction (PCR).In total, 61 patients were included. Of these, 38 patients (62.3%) had II polymorphism, 22 patients (36.1%) had ID polymorphism and 1 patient (1.6%) had DD polymorphism in the ACE gene. There were significant differences in the functional outcomes between patients without D allele (II polymorphisms) and patients with D allele (ID and DD polymorphism) (mean BI on discharge: 75 ± 23.57 and 60.65 ± 27.15, respectively; p = 0.034). Multiple linear regression model showed that the availability of D allele is an independent variable negatively associated with functional outcome as assessed by BI (β = -0.232, p = 0.024).This study showed that the D allele in ACE I/D polymorphism is associated with worse functional outcomes. This highlights the possibility of further research to improve functional outcomes of ischaemic stroke by inhibiting the ACE system. |
| Databáze: | OpenAIRE |
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