Tetracyclic Phenothiazines. VIII. Metal Hydride Reductions of Some 1,2-Dihydro-3-keto-3H-pyrido[3,2,1-kl]phenothiazines

Autor:	C. J. Grol, Arnold R. Martin, L. C. Vishwakarma, V. M. Paradkar
Jazyk:	angličtina
Rok vydání:	1982
Předmět:	Pharmacology Hydride Organic Chemistry Ether Borane Analytical Chemistry chemistry.chemical_compound Thioether chemistry Reagent Organic chemistry Hydroxymethyl Derivative (chemistry) Tetrahydrofuran
Zdroj:	HETEROCYCLES, 19(8), 1453-1461
ISSN:	0385-5414 1453-1461
DOI:	10.3987/R-1982-08-1453
Popis:	Aluminum hydride (alane) in ether reduces 1,2-dihydro-3-keto-3H-pyrido[3,2,1-kl]phenothiazines bearing hydrogen, thioether or dimethylaminomethyl substituents at the 2-position to the respective hydrocarbons. In the corresponding 2-carbethoxy derivative (a β-ketoester), the ester group is reduced to a hydroxymethyl or methyl function depending on the amount of reagent and its mode of generation. Reductions with borane in tetrahydrofuran afford mixtures of the corresponding hydrocarbons, alcohols and occasionally alkenes in varying amounts depending on the nature of the 2-substituent.
Databáze:	OpenAIRE
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