Hemostatic effect of recombinant factor VIIa, NN1731 and recombinant factor VIII on needle-induced joint bleeding in hemophilia A mice
Autor: | K. Øvlisen, Mikael Tranholm, Annemarie T. Kristensen, J. Ingerslev, N. Hakobyan, L. A. Valentino |
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Rok vydání: | 2008 |
Předmět: |
medicine.medical_specialty
Hemophilic arthropathy Hemorrhage Factor VIIa In Vitro Techniques Hemophilia A Recombinant factor viii Mice Animal model Synovitis Hemarthrosis medicine Animals Humans Joint bleeding Mice Knockout Hemostasis Factor VIII biology business.industry Coagulants Hematology Factor VII medicine.disease Recombinant Proteins Surgery Mice Inbred C57BL Disease Models Animal Degenerative arthritis Recombinant factor VIIa Needles biology.protein business |
Zdroj: | Ovlisen, K, Kristensen, A T, Valentino, L A, Hakobyan, N, Ingerslev, J & Tranholm, M 2008, ' Hemostatic effect of recombinant factor VIIa, NN1731 and recombinant factor VIII on needle-induced joint bleeding in hemophilia A mice ', Journal of Thrombosis and Haemostasis, vol. 6, no. 6, pp. 969-75 . https://doi.org/10.1111/j.1538-7836.2008.02954.x |
ISSN: | 1538-7836 |
DOI: | 10.1111/j.1538-7836.2008.02954.x |
Popis: | Udgivelsesdato: 2008-Jun BACKGROUND: Hemophilia A is the most common serious bleeding disorder, and the hallmark of this disease is joint bleeding episodes. These result in hemophilic synovitis, an inflammatory and proliferative condition of the joint, which progresses into a chronic degenerative arthritis, hemophilic arthropathy. METHODS: In this paper, we describe the effect of recombinant factor VIIa (rFVIIa), and an analogue NN1731 as well as rFVIII on needle-induced bleeding in hemophilia A mice. CONCLUSIONS: Here we show a reducing effect of rFVIIa and NN1731 on bleeding induced in hemophilic mice, and we show that preventive treatment with rFVIII normalizes bleeding. |
Databáze: | OpenAIRE |
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