46 XX male syndrome with hypogonadotropic hypogonadism: A case report
| Autor: | Ferda Percin, Göksun Ayvaz, Cigdem Ozkan, Mehmet Muhittin Yalcin, Nuri Cakir, Alev Eroglu Altinova, Ayhan Karakoç, Mujde Akturk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Infertility
Pediatrics medicine.medical_specialty endocrine system Pituitary macroadenoma medicine.drug_class XX male syndrome lcsh:Medicine 030209 endocrinology & metabolism Case Report 03 medical and health sciences 0302 clinical medicine Hypergonadotropic hypogonadism Hypogonadotropic hypogonadism Pituitary adenoma Medicine 46 XX male hypogonadism Testosterone lcsh:R5-920 030219 obstetrics & reproductive medicine business.industry infertility 46 xx male lcsh:R medicine.disease Gonadotropin business lcsh:Medicine (General) General Economics Econometrics and Finance hormones hormone substitutes and hormone antagonists |
| Zdroj: | İstanbul Kuzey Klinikleri, Vol 6, Iss 3, Pp 308-311 (2019) Northern Clinics of Istanbul |
| ISSN: | 2148-4902 |
| Popis: | We report a 46 XX male syndrome diagnosed after failure of gonadotropin therapy taken for hypogonadotropic hypogonadism due to a pituitary macroadenoma. A 39-year-old man with a non-functioning pituitary macroadenoma was admitted to our clinic due to vision loss and infertility. After pituitary surgery, vision loss improved while infertility still existed. Low testosterone levels without elevated gonadotropins were established suggesting hypogonadotropic hypogonadism due to pituitary adenoma. Gonadotropin treatment was initiated. There was no response to treatment after 12 months. A karyotype analysis was ordered to investigate other causes of infertility. Karyotype analysis showed a 46 XX male syndrome that can explain the failure of gonadotropin therapy. Testosterone therapy was started instead of gonadotropin therapy. 46 XX male syndrome usually presents with hypergonadotropic hypogonadism. However, in our case, it presented with hypogonadotropic hypogonadism due to pituitary mass not responding to gonadotropin therapy. It is important to keep in mind to obtain a genetic analysis of patients whose gonadotropin therapy failed, even if their gonadotropin levels are not elevated. |
| Databáze: | OpenAIRE |
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