Physiologic Leg Bowing is not a Physiologic Condition but Instead is Associated with Vitamin D Disorders in Toddlers
| Autor: | Mitsuyoshi Suzuki, Yuko Sakamoto, Satoshi Nakano, Akifumi Tokita, Masahiko Nozawa, Muneaki Ishijima, Lizu Liu, Sung-Gon Kim, Kazuo Kaneko, Toshiaki Shimizu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Genu varum Parathyroid hormone 030209 endocrinology & metabolism Rickets Gastroenterology Phosphates Young Adult 03 medical and health sciences Child Development 0302 clinical medicine Endocrinology Japan Genu Varum Internal medicine Prevalence medicine Vitamin D and neurology Humans Blood test Orthopedics and Sports Medicine Vitamin D Child medicine.diagnostic_test business.industry Metabolic disorder Age Factors Odds ratio Alkaline Phosphatase Vitamin D Deficiency medicine.disease body regions Bone Diseases Metabolic Parathyroid Hormone Case-Control Studies Child Preschool Alkaline phosphatase Calcium Female 030101 anatomy & morphology medicine.symptom business |
| Zdroj: | Calcified Tissue International. 106:95-103 |
| ISSN: | 1432-0827 0171-967X |
| Popis: | When children around 2-year-old show leg bowing without lower-limb radiographic abnormalities for rickets, the leg bowing is classified as “physiologic” genu varum without conducting a blood test. However, it has recently been suggested that toddlers who are diagnosed with physiologic genu varum may in fact have some form of bone metabolic disorder. In this 1:2 case–control study, blood samples were obtained from 33 toddlers with genu varum without radiographic abnormalities for rickets and 66 age- and gender-matched healthy children. Serum alkaline phosphatase (sALP), intact parathyroid hormone (siPTH), 25-hydroxy vitamin D [s25(OH)D], calcium (sCa), and inorganic phosphate (sP) were measured. s25(OH)D of the subjects with genu varum (24.8 ng/ml) were significantly lower than those of the control (33.6 ng/ml) (p |
| Databáze: | OpenAIRE |
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