Among young Sri Lankan patients with diabetes, how do lipid profiles differ between those with and without metabolic syndrome?
| Autor: | Brian Shine, David R. Matthews, Gaya Katulanda, H. A. Dissanayake, Prasad Katulanda |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Apolipoprotein B Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine Prevalence Humans Risk factor Sri Lanka Metabolic Syndrome biology business.industry Cholesterol Cholesterol HDL General Medicine medicine.disease Prognosis Lipids Endocrinology chemistry Diabetes Mellitus Type 2 Case-Control Studies Apolipoprotein B-100 biology.protein lipids (amino acids peptides and proteins) Female Metabolic syndrome business Dyslipidemia Biomarkers Follow-Up Studies |
| Zdroj: | Diabetesmetabolic syndrome. 13(5) |
| ISSN: | 1878-0334 |
| Popis: | Metabolic syndrome (MetS) is a risk factor for cardiovascular disease (CVD). Apolipoproteins are emerging as powerful predictors of CVD. We aimed to study associations of metabolic syndrome and apoB, apoAI, apoB/AI ratio in young Sri Lankans with type 2 diabetes.Blood samples were available from 690 patients with type 2 diabetes in Sri Lanka Young Diabetes Study, and were analysed for apoB, apoAI, total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), triglycerides (TG) and glycated haemoglobin (HbAMetS was present in 60.9% of subjects. Of those with MetS, 76.0% were women. Those with MetS had higher apoB (1.27 V s 1.19 mmol/L; p = 0.001), apoB/AI (0.80 V s 0.75; p = 0.001), non-HDL cholesterol (NHDLC) (4.15 V s 3.98 mmol/L; p = 0.002),and triglycerides (1.51 V s 1.31 mmol/L; p 0.001) and lower apoAI (1.58 V s 1.60 mmol/L; p = 0.03) and HDLC (1.02 V s 1.16 mmol/L, p 0.001). ApoB and apoB/AIlevels increased significantly as the number of MetS components increased. ApoB and apoB:AI ratio were independently associated with MetS and components.MetS showed a high prevalence among young Sri Lankans with diabetes. Elevated apoB is commonly clustered with other risk indicators in MetS. |
| Databáze: | OpenAIRE |
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