The therapeutic effect of OK-432-combined adoptive immunotherapy against liver metastases from gastric or colorectal cancers
| Autor: | Takashi Okino, Kohei Satoh, Taisuke Hori, Norimichi Kan, Seiji Yamasaki, Kazuhisa Ohgaki, Takayoshi Tobe, Keiichi Mise, Takehisa Harada |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Adoptive cell transfer medicine.medical_specialty Pathology Colorectal cancer medicine.medical_treatment Lymphocyte Activation Immunotherapy Adoptive Gastroenterology Metastasis Picibanil Antigens Neoplasm Stomach Neoplasms Internal medicine Adjuvant therapy Humans Medicine Cytotoxic T cell Lymph node Aged Pharmacology business.industry Liver Neoplasms Immunotherapy Middle Aged medicine.disease medicine.anatomical_structure Interleukin-2 Female Lymph Colorectal Neoplasms business |
| Zdroj: | Biotherapy. 6:41-49 |
| ISSN: | 1573-8280 0921-299X |
| Popis: | Twenty-four patients with liver metastases from gastric or colorectal cancer were treated with OK-432-combined adoptive immunotherapy (AIT). Lymphocytes isolated from regional lymph nodes or peripheral blood were cultured with medium containing T cell growth factor and sonicated tumor extract antigen (SE-Ag) for 9–13 days. The cultured lymphocytes were transferred mainly through the hepatic artery after the administration of OK-432, a streptococcal preparation. Sixteen of the 24 patients received a low dose of anti-cancer agents between the OK-432 injection and cell transfer. When cultured without SE-Ag, regional lymph node lymphocytes (RLNL) showed significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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