Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese

Autor: Yu Cho Woo, Bernard M.Y. Cheung, A. Z. L. Shih, Chi-Hang Lee, Carol H.Y. Fong, Kwok-Tai Lam, Edward D Janus, O. Y. Leung
Rok vydání: 2016
Předmět:
endocrine system diseases
Physiology
lcsh:Medicine
Blood Pressure
Type 2 diabetes
030204 cardiovascular system & hematology
Biochemistry
Vascular Medicine
Impaired glucose tolerance
0302 clinical medicine
Endocrinology
Medicine and Health Sciences
Medicine
Homeostasis
Prospective Studies
lcsh:Science
Prospective cohort study
Glucose Tolerance
education.field_of_study
Multidisciplinary
Lipids
Type 2 Diabetes
Cholesterol
Research Design
Cohort study
Research Article
medicine.medical_specialty
Endocrine Disorders
Population
030209 endocrinology & metabolism
Research and Analysis Methods
03 medical and health sciences
Insulin resistance
Diagnostic Medicine
Internal medicine
Diabetes Mellitus
education
Endocrine Physiology
business.industry
lcsh:R
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
Biology and Life Sciences
medicine.disease
Impaired fasting glucose
Metabolism
Metabolic Disorders
Glucose Tolerance Tests
lcsh:Q
Insulin Resistance
business
Physiological Processes
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0163424 (2016)
ISSN: 1932-6203
Popis: BACKGROUND: The optimal reference range of homeostasis model assessment of insulin resistance (HOMA-IR) in normal Chinese population has not been clearly defined. Here we address this issue using the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS), a prospective population-based cohort study with long-term follow-up. MATERIAL & METHODS: In this study, normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) were defined according to the 1998 World Health Organization criteria. Dysglycemia referred to IFG, IGT or T2DM. This study comprised two parts. Part one was a cross-sectional study involving 2,649 Hong Kong Chinese subjects, aged 25-74 years, at baseline CRISPS-1 (1995-1996). The optimal HOMA-IR cut-offs for dysglycemia and T2DM were determined by the receiver-operating characteristic (ROC) curve. Part two was a prospective study involving 872 subjects who had persistent NGT at CRISPS-4 (2010-2012) after 15 years of follow-up. RESULTS: At baseline, the optimal HOMA-IR cut-offs to identify dysglyceia and T2DM were 1.37 (AUC = 0.735; 95% confidence interval [CI] = 0.713-0.758; Sensitivity [Se] = 65.6%, Specificity [Sp] = 71.3%] and 1.97 (AUC = 0.807; 95% CI = 0.777-0.886; Se = 65.5%, Sp = 82.9%) respectively. These cut-offs, derived from the cross-sectional study at baseline, corresponded closely to the 75th (1.44) and 90th (2.03) percentiles, respectively, of the HOMA-IR reference range derived from the prospective study of subjects with persistent NGT. CONCLUSIONS: HOMA-IR cut-offs, of 1.4 and 2.0, which discriminated dysglycemia and T2DM respectively from NGT in Southern Chinese, can be usefully employed as references in clinical research involving the assessment of insulin resistance.
published_or_final_version
Databáze: OpenAIRE
Externí odkaz: