Mutagenicity studies with N-acetyl-l-aspartic acid
| Autor: | Sule Karaman, Susan M. Munley, Bryan Delaney, Abby Myhre, E. Maria Donner |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Salmonella typhimurium
endocrine system Mutagen Biology Toxicology medicine.disease_cause Mice Clastogen Bone Marrow In vivo mental disorders Aspartic acid Escherichia coli medicine Animals chemistry.chemical_classification Aspartic Acid Mice Inbred ICR Micronucleus Tests Mutagenicity Tests food and beverages General Medicine In vitro nervous system diseases Amino acid nervous system Biochemistry chemistry Micronucleus test Genotoxicity Mutagens Food Science |
| Zdroj: | Food and Chemical Toxicology. 47:1936-1940 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2009.05.005 |
| Popis: | Analytical studies have reported that N-acetyl- l -aspartic acid (NAA) is present at low concentrations in many foods. The current studies were conducted to assess the mutagenicity of NAA using standard OECD guideline in vitro bacterial and in vivo mammalian mutagenicity studies. For comparison and control data, mutagenicity studies were also conducted with its constituent amino acid l -aspartate (ASP) because NAA is metabolized to ASP. The combination of an in vitro method for assessing point mutations in bacteria and an in vivo method to assess clastogenicity in an animal model provided adequate evidence for mutagenicity hazard assessment of NAA. No evidence of mutagenicity was observed in either test system with either NAA or ASP. The results from the current studies demonstrate that the presence of NAA in foods is not likely to represent a risk for mutagenicity. |
| Databáze: | OpenAIRE |
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