Inhaled nitric oxide improves pulmonary hypertension and organ functions after adult heart valve surgeries
| Autor: | Takeichiro Nakane, Ryoma Ueda, Jiro Esaki, Hitoshi Okabayashi, Masanori Honda |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine medicine.medical_specialty Hypertension Pulmonary Vasodilator Agents 030232 urology & nephrology Hemodynamics 030204 cardiovascular system & hematology Nitric Oxide Nitric oxide law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Administration Inhalation Cardiopulmonary bypass Humans Medicine Heart valve Cardiac Surgical Procedures Inhalation business.industry General Medicine medicine.disease Heart Valves Pulmonary hypertension Cardiac surgery medicine.anatomical_structure chemistry Cardiothoracic surgery Anesthesia Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | General Thoracic and Cardiovascular Surgery. 69:1519-1526 |
| ISSN: | 1863-6713 1863-6705 |
| DOI: | 10.1007/s11748-021-01651-z |
| Popis: | Pulmonary hypertension during cardiac surgery is associated with increased morbidity and mortality. Inhaled nitric oxide serves as a selective pulmonary vasodilator and has other potential extrapulmonary protective roles. Its effects on pulmonary hypertension and organ functions after adult valve surgeries were evaluated. From April 2017 to March 2000, 30 patients received inhaled nitric oxide therapy for pulmonary hypertension during weaning from cardiopulmonary bypass in valvular surgery (iNO group). The group was compared with a control group of 65 patients who developed pulmonary hypertension during weaning from cardiopulmonary bypass in valvular surgery and received conventional therapy from April 2014 to March 2017. Intraoperative hemodynamic changes and postoperative Sequential Organ Failure Assessment (SOFA) score were evaluated. The inhalation of nitric oxide lowered the pulmonary-to-systemic pressure ratio (Pp/Ps) (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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