MURINE PULMONARY RESPONSE TO CHRONIC HYPOXIA IS STRAIN SPECIFIC
| Autor: | Michelle Carr, Sven Laudi, Charles Ivester, Julie W. Harral, James West, Nobuhiro Tanabe, Koichiro Tatsumi, Yuichi Takiguchi, Yuji Tada, William C. Nichols, Takayuki Kuriyama |
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| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Heart Ventricles Clinical Biochemistry Mice Inbred Strains Biology Article Electrocardiography Mice Species Specificity Internal medicine Genetic variation Gene expression medicine Animals Genetic Predisposition to Disease RNA Messenger Hypoxia Lung Molecular Biology Gene Oligonucleotide Array Sequence Analysis Regulation of gene expression Gene Expression Profiling Genomics Hypoxia (medical) Phenotype Molecular biology Gene expression profiling Endocrinology Gene Expression Regulation Hematocrit Chronic Disease Ventricular Function Right Ventricular pressure medicine.symptom |
| Zdroj: | Experimental Lung Research. 34:313-323 |
| ISSN: | 1521-0499 0190-2148 |
| Popis: | Information concerning the effects of genetic variation between different background strains on hemodynamic, morphometric, and gene expression response to hypoxia would be useful. Three strains of mice were kept in hypoxia and phenotyped followed by gene profiling analysis. Among the variables examined, hematocrit, right heart muscularization, and right ventricular systolic pressure showed a strain-specific effect. Increased gene expression of inflammatory, muscle, and angiogenesis genes were seen in all strains, though the specific genes changed varied among groups. These results suggest that different strains use different gene expression mechanisms to adapt to the challenge of chronic hypoxia, resulting in modified phenotypic changes. |
| Databáze: | OpenAIRE |
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