'Picrosides' from Picrorhiza kurroa as potential anti-carcinogenic agents
| Autor: | Abhinav Grover, Deepika Soni |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Picrorhiza kurroa Phytochemicals Iridoid Glucosides Anti-Carcinogenic Agents Apoptosis RM1-950 Pharmacology Detoxification enzymes medicine.disease_cause Anti-oxidant Antioxidants Modern life 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Animals Anticarcinogenic Agents Humans Carcinogen Cancer Picrorhiza Plants Medicinal business.industry General Medicine medicine.disease Cancer treatment 030104 developmental biology Anticancer agent Picrosides Cinnamates 030220 oncology & carcinogenesis Therapeutics. Pharmacology business Carcinogenesis |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 109, Iss, Pp 1680-1687 (2019) |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2018.11.048 |
| Popis: | The steady rise in life expectancy, modern life style and changing environmental conditions are responsible for increasing incidence of cancer. A number of chemical drugs have been used for cancer treatment; however the induction of genotoxic, carcinogenic and teratogenic effects limits their use. Alternatively, plant phytochemicals have been proven effective chemopreventive agents. This review illustrates the use of “picrosides” derived from Picrorhiza kurroa for the treatment of cancer. We have detailed the anti-oxidant and anti-inflammatory action of picrosides as the key mechanism in reducing oncogenesis. Action of picrosides on detoxifying enzymes, cell cyle regulation and induction of signal transducers inhibiting apoptosis has also been reviewed. The present review highlights the use of picrosides as an important therapeutic agent against different types of cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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