Endovascular Photodynamic Therapy with Aminolaevulinic Acid Prevents Balloon Induced Intimal Hyperplasia and Constrictive Remodelling
| Autor: | R. Van Hillegersberg, Edward E.E. Gabeler, Paul G.H. Mulder, H. van Urk, R. G. Statius van Eps, Wim Sluiter |
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| Přispěvatelé: | Surgery, Biochemistry, Epidemiology |
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Pathology Time Factors Intimal hyperplasia medicine.medical_treatment Urology Photodynamic therapy Constriction Pathologic Constriction Nitric oxide Random Allocation chemistry.chemical_compound Restenosis Angioplasty medicine Animals Rats Wistar Medicine(all) Hyperplasia Photosensitizing Agents Dose-Response Relationship Drug business.industry Aminolevulinic Acid medicine.disease Rats Disease Models Animal Dose–response relationship medicine.anatomical_structure Photochemotherapy chemistry ALA Endovascular PDT IH Light dosimetry Cholinergic innervation Remodelling Stenosis model Surgery Tunica Intima Cardiology and Cardiovascular Medicine business Angioplasty Balloon Blood vessel |
| Zdroj: | European Journal of Vascular and Endovascular Surgery, 24, 322-331. W.B. Saunders |
| ISSN: | 1078-5884 |
| DOI: | 10.1053/ejvs.2002.1723 |
| Popis: | Background and Objective: intimal hyperplasia (IH) and constrictive remodelling are important causes of restenosis following endovascular interventions, such as percutaneous transluminal angioplasty. Photodynamic therapy (PDT) with 5-aminolaevulinic (ALA) may prevent restenosis by cellular depletion and the elimination of cholinergic innervation. Study design/Materials and Methods: rats (n = 90) were subdivided into 4 main groups. In the experimental group (n = 36: 3 replications x 4 doses x 3 examination time-points), ALA was administered (200 mg/kg i.v.) 2-3 h before balloon injury (BI) of the common iliac artery followed by endovascular illumination with 633 nm at either 12.5, 25, 50 or 100 J/cm diffuser length (dl BI + PDT group). As control groups served the BI + Light only (LO) group (n = 36) that received no ALA, the BI only group (n = 9) (BI), and a group (n = 9) that received a Sham procedure (Sham group). Results: planimetric analysis showed IH of 0.28 +/- 0.12 mm(2) (BI), 0.27 +/- 0.12 mm(2) (BI + LO at 100 J/cm dl) in contrast to 0.02 +/- 0.02 mm(2) after BI + PDT at 100 J/cm dl at 16 weeks (p |
| Databáze: | OpenAIRE |
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