Effects of multi-domain lifestyle interventions on sarcopenia measures and blood biomarkers: secondary analysis of a randomized controlled trial of community-dwelling pre-frail and frail older adults
| Autor: | Yanxia Lu, Mathew Niti, Boon Yeow Tan, Anis Larbi, Keng Bee Yap, Ma Shwe Zin Nyunt, Sue Anne Khoo, Tze Pin Ng, Sue Mei Chan, Crystal Tze Ying Tan, Gribson Chan, Philip Yap, Liang Feng |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Sarcopenia Aging medicine.medical_specialty Anabolism Frail Elderly Psychological intervention Physical exercise law.invention Randomized controlled trial law Internal medicine homeostasis medicine Humans Muscle Strength Exercise Life Style Aged Cognitive Intervention Frailty business.industry lifestyle intervention Cell Biology medicine.disease Cognitive training Treatment Outcome inflammation randomized controlled trial Lean body mass Female Independent Living business human activities Biomarkers Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Few studies have comprehensively described changes in blood biomarkers of the physiological responses underlying sarcopenia reduction associated with lifestyle interventions. In this study, we performed secondary analyses of data in a randomized controlled trial of multi-domain lifestyle interventions (6-month duration physical exercise, nutritional enrichment, cognitive training, combination and standard care control) among 246 community-dwelling pre-frail and frail elderly, aged ≥65 years, with and without sarcopenia. Appendicular lean mass (ALM), lower limb strength, gait speed, and blood levels of markers of muscle metabolism, inflammation, anti-oxidation, anabolic hormone regulation, insulin signaling, tissue oxygenation were measured at baseline, 3-month and 6-month post-intervention. Multi-domain interventions were associated with significant (p < 0.001) reduction of sarcopenia at 3-month and 6-month post-intervention, improved gait speed, enhanced lower limb strength, and were equally evident among sarcopenic participants who were slower at baseline than non-sarcopenic participants. Active intervention was associated with significantly reduced inflammation levels. Sarcopenia status and reduction were associated with blood biomarkers related to muscle metabolism, steroid hormone regulation, insulin-leptin signaling, and tissue oxygenation. Physical, nutritional and cognitive intervention was associated with measures of sarcopenia reduction, together with changes in circulating biomarkers of anabolic and catabolic metabolism underlying sarcopenia. |
| Databáze: | OpenAIRE |
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