Altered onset response dynamics in somatosensory processing in autism spectrum disorder
| Autor: | Keri-Lee A. Garel, Hari M. Bharadwaj, Matti Hämäläinen, Javeria A. Hashmi, Manfred G. Kitzbichler, Manuel Zetino, Tal Kenet, Santosh Ganesan, Sheraz Khan, Fahimeh Mamashli, Konstantinos P. Michmizos |
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| Přispěvatelé: | Kitzbichler, Manfred [0000-0002-4494-0753], Apollo - University of Cambridge Repository, Massachusetts Institute of Technology, Dalhousie University, Harvard Medical School, Massachusetts General Hospital, The State University of New Jersey, University of Cambridge, Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, Aalto University |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Somatosensory system ta3112 Feedback Feedforward 03 medical and health sciences 0302 clinical medicine mental disorders medicine Magnetoencephalography (MEG) Cortical connectivity Tactile sensing Original Research Psychiatry medicine.diagnostic_test Mechanism (biology) autism spectrum disorders (ASD) General Neuroscience Functional connectivity Magnetoencephalography Biomarker medicine.disease Autism spectrum disorders (ASD) Somatosensory cortex 030104 developmental biology medicine.anatomical_structure Autism spectrum disorder Autism Psychology Neuroscience Tactile processing 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Frontiers in Neuroscience |
| ISSN: | 1662-453X |
| DOI: | 10.3389/fnins.2016.00255 |
| Popis: | Abnormalities in cortical connectivity and evoked responses have been extensively documented in autism spectrum disorder (ASD). However, specific signatures of these cortical abnormalities remain elusive, with data pointing toward abnormal patterns of both increased and reduced response amplitudes and functional connectivity. We have previously proposed, using magnetoencephalography (MEG) data, that apparent inconsistencies in prior studies could be reconciled if functional connectivity in ASD was reduced in the feedback (top-down) direction, but increased in the feedforward (bottom-up) direction. Here, we continue this line of investigation by assessing abnormalities restricted to the onset, feedforward inputs driven, component of the response to vibrotactile stimuli in somatosensory cortex in ASD. Using a novel method that measures the spatio-temporal divergence of cortical activation, we found that relative to typically developing participants, the ASD group was characterized by an increase in the initial onset component of the cortical response, and a faster spread of local activity. Given the early time window, the results could be interpreted as increased thalamocortical feedforward connectivity in ASD, and offer a plausible mechanism for the previously observed increased response variability in ASD, as well as for the commonly observed behaviorally measured tactile processing abnormalities associated with the disorder. |
| Databáze: | OpenAIRE |
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