cnm-Positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral hemorrhage
| Autor: | Keisuke Tachiyama, Yuki Hayashi, Tatsuo Kohriyama, Shiro Aoki, Kazuhiko Nakano, Tomohisa Nezu, Teppei Kamimura, Eiji Imamura, Masahiro Nakamori, Hayato Matsushima, Ryota Nomura, Hiroki Ueno, Shinichi Wakabayashi, Hirofumi Maruyama, Yuji Shiga, Ryo Shimomura, Naoto Kinoshita, Naohisa Hosomi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Gastroenterology Streptococcus mutans 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Humans In patient cardiovascular diseases 030212 general & internal medicine Adhesins Bacterial Cerebral Hemorrhage Intracerebral hemorrhage biology business.industry medicine.disease biology.organism_classification Magnetic Resonance Imaging Hyperintensity nervous system diseases Diffusion Magnetic Resonance Imaging Neurology Neurology (clinical) business Carrier Proteins 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | European journal of neurologyREFERENCES. 28(5) |
| ISSN: | 1468-1331 |
| Popis: | Strains of Streptococcus mutans expressing the cell surface collagen-binding protein, Cnm, encoded by cnm (cnm-positive S. mutans), are associated with hypertensive intracerebral hemorrhage (ICH) and the occurrence of cerebral microbleeds (CMBs). Small diffusion-weighted imaging (DWI) hyperintensities in patients with acute ICH are also associated with CMBs. However, the association between cnm-positive S. mutans and DWI hyperintensities is unclear. Hence, this study aimed to investigate the association between cnm-positive S. mutans and DWI hyperintensities in patients with acute ICH.Patients with acute ICH were prospectively registered at three hospitals. Dental plaque specimens were collected within 4 days after admission, and cnm-positive S. mutans was detected using the polymerase chain reaction. Magnetic resonance imaging at 14 ± 5 days after admission was used to evaluate DWI hyperintensities and CMBs.A total of 197 patients were enrolled in this study. cnm-positive S. mutans was detected in 30 patients (15.2%), and DWI hyperintensities were observed in 56 patients (28.4%). Patients with cnm-positive S. mutans had a higher frequency of DWI hyperintensities (50.0% vs 24.6%; p = 0.008) and a higher number of CMBs (5.5 vs 1.5; p 0.001) than those without cnm-positive S. mutans. Multivariable logistic analysis revealed that the presence of cnm-positive S. mutans was independently associated with DWI hyperintensities (OR 2.38; 95% CI 1.01-5.61; p = 0.047) after adjusting for several confounding factors.This study found an association between the presence of cnm-positive S. mutans and DWI hyperintensities in patients with acute ICH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text