Bacterial DNA Translocation and Liver Disease Severity Among HIV-Infected Patients With Chronic Hepatitis C
| Autor: | Ana Carrero, Salvador Resino, Emilio Álvarez, Amanda Fernández-Rodríguez, María Guzmán-Fulgencio, Jaime Cosín, M Angeles Jimenez-Sousa, Teresa Aldámiz-Echevarría, Mónica García-Álvarez, Pilar Miralles, Dariela Micheloud, Juan Berenguer |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
DNA Bacterial Liver Cirrhosis Male Biological Transport Active HIV Infections Chromosomal translocation Virus Liver disease Chronic hepatitis Acquired immunodeficiency syndrome (AIDS) RNA Ribosomal 16S medicine Humans Hiv infected patients Pharmacology (medical) Intestinal Mucosa Base Sequence medicine.diagnostic_test business.industry Hepatitis C Hepatitis C Chronic medicine.disease Cross-Sectional Studies Infectious Diseases Liver biopsy Immunology Disease Progression Female business |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 61:552-556 |
| ISSN: | 1525-4135 |
| Popis: | We carried out a cross-sectional study to explore whetherbacterial 16Sribosomal DNA (bactDNA) shows association with severityof liver disease among human immunode ficiency virus/hepatitis C viruscoinfected patients. Patients with advanced fibrosis (F3/F4), moderateactivity grade (A2/A3), and high fibrosis progression rate (FPR . 0.15)had higher values of plasma bactDNA levels than did patients withoutthese markers of liver disease ( P, 0.05). The chance of having a fibrosisstage or activity grade increased was 1.20 [95% con fidence interval (CI)= 1.0 to 1.44, P = 0.045] and 1.22 (95% CI = 1.1 to 1.45, P = 0.029)times greater for every 100 copies per microliter of plasma bactDNA.Likewise, the odds of having values of FPR . 0.15 was 1.18 (95%CI=0.98to1.42,P = 0.089). In addition, patients with high bactDNAlevels ($175 copies per microliter) had t he highest odds of having highvalues ofMetavir scoreandFPR( P, 0.05). Our data show that bacterialtranslocation is associated with severe liver disease among humanimmunodeficiency virus–infected patients with chronic hepatitis C.Key Words: 16S rDNA, bacterial translocation, hepatitis C, HIV/AIDS, liver biopsy(J Acquir Immune Defic Syndr 2012;61:552–556) |
| Databáze: | OpenAIRE |
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