Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC)
| Autor: | Chia Ee Lee, Vui King Vincent-Chong, Mannil Thomas Abraham, Lukman Bin Md Auzair, Wan Maria Nabillah Ghani, Thomas George Kallarakkal, Anand Ramanathan, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Rosnah Binti Zain |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Protein subunit Caveolin 1 Cell medicine.disease_cause Actin-Related Protein 2-3 Complex 03 medical and health sciences symbols.namesake 0302 clinical medicine Biomarkers Tumor medicine Humans RNA Neoplasm Actin-Related Protein 2/3 Complex Subunit 1B Gene Fisher's exact test Neoplasm Staging Proportional hazards model business.industry General Medicine Middle Aged Prognosis Immunohistochemistry Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell symbols Cancer research Female Mouth Neoplasms Carcinogenesis business |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 273:1885-1893 |
| ISSN: | 1434-4726 0937-4477 |
| DOI: | 10.1007/s00405-015-3703-9 |
| Popis: | Caveolin-1 (Cav-1) and Actin-Related Protein 2/3 Complex, Subunit 1B (ARPC1B) have been implicated in various human cancers, yet its role in tumorigenesis remains controversial. Therefore, this study aims to determine the protein expression of these two genes in oral squamous cell carcinomas (OSCCs) and to evaluate the clinical and prognostic impact of these genes in OSCC. Protein expressions of these two genes were determined by immunohistochemistry technique. The association between Cav-1 and ARPC1B with clinico-pathological parameters was evaluated by Chi-square test (or Fisher exact test where appropriate). Correlation between the protein expressions of these 2 genes with survival was analyzed using Kaplan-Meier and Cox regression models. Cav-1 and ARPC1B were found to be significantly over-expressed in OSCC compared to normal oral mucosa (p = 0.002 and p = 0.033, respectively). Low level of ARPC1B protein expression showed a significant correlation with lymph node metastasis (LNM) (p = 0.010) and advanced tumor staging (p = 0.003). Kaplan-Meier survival analyses demonstrated that patients with over-expression of Cav-1 protein were associated with poor prognosis (p = 0.030). Adjusted multivariate Cox regression model revealed that over-expression of Cav-1 remained as an independent significant prognostic factor for OSCC (HRR = 2.700, 95 % CI 1.013-7.198, p = 0.047). This study demonstrated that low-expression of ARPC1B is significantly associated with LNM and advanced tumor staging whereas high expression of Cav-1 can be a prognostic indicator for poor prognosis in OSCC patients. |
| Databáze: | OpenAIRE |
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