Nevirapine-Based Regimens in Routine Clinical Settings: Results from a Large Italian Cohort of HIV-1 Infected Adults
| Autor: | Anna Orani, Antonio Di Biagio, Claudio Viscoli, Raffaella Rosso, Roberto Rossotti, Laura Ambra Nicolini, Fulvio Adorni |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Nevirapine Databases Factual Anti-HIV Agents Population HIV Infections Toxicology Cohort Studies Young Adult Sex Factors Risk Factors Internal medicine HBV medicine Humans Pharmacology (medical) education Aged Dyslipidemias Retrospective Studies Pharmacology education.field_of_study business.industry Age Factors Retrospective cohort study Hepatitis C Middle Aged Hepatitis B medicine.disease Co-infection CD4 Lymphocyte Count Discontinuation Cholesterol Treatment Outcome Dyslipidemia Italy HCV Cohort Immunology HIV-1 Female business medicine.drug Cohort study |
| Zdroj: | Current drug safety 6 (2011): 138–144. doi:10.2174/157488611797579339 info:cnr-pdr/source/autori:Rosso R.; Rossotti R.; Di Biagio A.; Nicolini L.; Adorni F.; Orani A.; Viscoli C./titolo:Nevirapine-based regimens in routine clinical settings: Results from a large italian cohort of HIV-1 infected adults/doi:10.2174%2F157488611797579339/rivista:Current drug safety (Print)/anno:2011/pagina_da:138/pagina_a:144/intervallo_pagine:138–144/volume:6 |
| ISSN: | 1574-8863 |
| Popis: | We assessed the safety and efficacy of different nevirapine-based regimens in patients starting this drug in a large cohort of Caucasian subjects during the 1999-2007 periods. Methods. A retrospective database review of all patients receiving nevirapine was performed; clinical, biochemical (hepatic and metabolic profiles), immuno-virological parameters were evaluated in the overall population and in different subgroups (according to gender, therapy-experience and HBV/HCV co-infection). We determined risk factors related to dyslipidemia development and to nevirapine interruption within 1 year. Results. We evaluated 277 patients; 58 (20.9%) were naïve, 180 (65%) females and 137 (49.5%) HBV/HCV co-infected. After 48 weeks, 73.6% patients continued antiretroviral regimens. Among these, nevirapine showed little hepatic and metabolic impact, as well as good immuno-virological outcome despite sex, drug experience and co-infection. Factors related to development of dyslipidemia were higher in total cholesterol, female gender with high CD4 count and male gender with low CD4 count (p |
| Databáze: | OpenAIRE |
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