Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders

Autor: Julien Astier, Charlène Couturier, Lauriane Bonnet, Habib Hammou, Jean-François Landrier, Esma Karkeni, Franck Tourniaire, Soumia Fenni
Přispěvatelé: Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), LPNSA, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université Oran 1 Ahmed Ben Bella, Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Anti-Inflammatory Agents
Adipose tissue
Metabolic disease
tissu adipeux
tomato
chemistry.chemical_compound
tomate
Mice
Lycopene
Solanum lycopersicum
steatosis
Glucose homeostasis
2. Zero hunger
NF-kappa B
Adipose tissue carotenoids
Insulin sensitivity
carotenoid
3. Good health
sensibilité à l'insuline
obésité
Adipose Tissue
lycopène
Alimentation et Nutrition
Body Composition
medicine.symptom
Biotechnology
medicine.medical_specialty
Inflammation
Context (language use)
Biology
Diet
High-Fat
Proinflammatory cytokine
03 medical and health sciences
carotenoide
Metabolic Diseases
Internal medicine
medicine
activateur inhibiteur
Food and Nutrition
Animals
Obesity
Tomato product
stéatose
030109 nutrition & dietetics
medicine.disease
maladie métabolique
Lipid Metabolism
Carotenoids
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
Steatosis
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Food Science
Zdroj: Molecular Nutrition and Food Research
Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2017, pp.1601083. ⟨10.1002/mnfr.201601083⟩
Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2017, 61 (9), pp.1601083. ⟨10.1002/mnfr.201601083⟩
Molecular Nutrition and Food Research 9 (61), 1601083. (2017)
Molecular Nutrition and Food Research, 2017, 61 (9), pp.1601083. ⟨10.1002/mnfr.201601083⟩
ISSN: 1613-4133
1613-4125
DOI: 10.1002/mnfr.201601083⟩
Popis: cope Several studies have linked the high intake of lycopene or tomatoes products with lower risk for metabolic diseases. The aim of the present study was to evaluate and to compare the effect of lycopene and tomato powder on obesity-associated disorders. Methods and results Male C57BL/J6 mice were assigned into four groups to receive: control diet (CD), high fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks. In HFD condition, lycopene and TP supplementation significantly reduced adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α and improved glucose homeostasis, but did not affect total body weight. Lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes. Lycopene and TP decreased HFD-induced proinflammatory cytokine mRNA expression in the liver and in the epididymal adipose tissue. The anti-inflammatory effect of lycopene and TP was related to a reduction in the phosphorylation levels of IκB, and p65, and resulted in a decrease of inflammatory proteins in adipose tissue. Conclusion These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies.
Databáze: OpenAIRE
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