The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson’s Disease and Atypical Parkinsonisms—A Systematic Review
| Autor: | Sofija Antoniuk, Jakub Kufel, Joanna Siuda, Klaudia Adamczewska, Mateusz Toś, Anna Grażyńska, Weronika Urbaś, Martyna Bień |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Sleep Wake Disorders
Medicine (General) medicine.medical_specialty Parkinson's disease MEDLINE Disease Lower risk chemistry.chemical_compound R5-920 uric acid Parkinsonian Disorders Internal medicine medicine Humans Depression (differential diagnoses) Fatigue business.industry Parkinsonism Parkinson Disease General Medicine medicine.disease atypical Parkinsonism non-motor symptoms chemistry Parkinson’s disease cognitive disorders Uric acid Anxiety sleep disorders Systematic Review medicine.symptom business |
| Zdroj: | Medicina Medicina, Vol 57, Iss 972, p 972 (2021) |
| ISSN: | 1648-9144 1010-660X |
| Popis: | Background and Objectives: A growing number of studies correlated higher levels of serum uric acid (UA) with both: lower risk of Parkinson’s Disease (PD) occurrence and slower progression of the disease. Similar conclusions were made where studies correlated UA with atypical Parkinsonisms (AP) progression. A few researchers have studied the issue of the influence of serum UA on the occurrence of non-motor symptoms (NMS) in PD and AP. Our systematic review is the first review completely dedicated to this matter. Materials and Methods: A comprehensive evaluation of the literature was performed to review the relationship between UA and NMS in PD and AP. The systematic review was conducted according to PRISMA Statement guidelines. The following databases were searched starting in April 2021: MEDLINE via PubMed, Embase, and Scopus. During the research, the following filters were used: >2010, articles in English, concerning humans. The study was not registered and received no external funding. Results: Seven articles meeting all inclusion criteria were included in this study. Collectively, data on 1104 patients were analyzed. A correlation between serum UA concentration and a few NMS types has been provided by the analyzed studies. In four papers, sleep disorders and fatigue were related to UA for both advanced and early PD. Other commonly appearing NMS domains were Attention/memory (4 studies), Depression/anxiety (3 studies), Cardiovascular (3 studies), Gastrointestinal (1 study), Perceptual (1 study), and Miscellaneous (1 study). For AP, no significant correlation between UA and worsening of NMS has been found. Conclusions: Based on the analyzed studies, a correlation between serum UA level and the occurrence and worsening of NMS in PD and APs cannot be definitively determined. Large-scale studies with a more diverse patient population and with more accurate methods of NMS assessment in Parkinsonism are needed. |
| Databáze: | OpenAIRE |
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