From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis
| Autor: | Darya V. Evtushok, Olga A. Efremova, Ali M. Adawi, J. S. Bouillard, Anton A. Ivanov, Michael A. Shestopalov, Svetlana M. Miroshnichenko, Yuri V. Mironov, Vadim V. Yanshole, Yuri A. Vorotnikov, Maria S. Fufaeva, Charlotte J. Eling, Ilia V. Eltsov, Ekaterina V. Svezhentseva, Natalia V. Kuratieva, L. V. Shestopalova, Anastasiya O. Solovieva, Tatiana N. Pozmogova |
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| Rok vydání: | 2018 |
| Předmět: |
Models
Molecular Octahedral cluster Light Cell Survival chemistry.chemical_element Nanoparticle Antineoplastic Agents 02 engineering and technology Tungsten 010402 general chemistry Photochemistry 01 natural sciences Catalysis Hydrolysis Drug Stability Cell Line Tumor Neoplasms Humans Solubility Molybdenum Photosensitizing Agents Endoplasmic reticulum Organic Chemistry Hep G2 Cells General Chemistry Photochemical Processes 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Octahedron 0210 nano-technology |
| Zdroj: | Chemistry – A European Journal. 24:17915-17920 |
| ISSN: | 1521-3765 0947-6539 |
| Popis: | Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6 I8 }(DMSO)6 ](NO3 )4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum. |
| Databáze: | OpenAIRE |
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